Welcome to the
About
The Molecular Oncology Laboratory
The Molecular Oncology Laboratory is dedicated to advancing cancer research by unraveling the genomic landscape of response and resistance to cancer therapies, with a focus on immunotherapies. Our mission is to comprehensively study the genomic wiring of tumor and immune system interactions and bridge scientific discoveries with clinical cancer care. Through cutting-edge integrative genomic, transcriptomic, single-cell, and liquid biopsy analyses, we aim to capture tumor evolution as the cancer cells undergo therapy-imposed bottlenecks and translate the lessons learned into interventions that improve the clinical outcomes of individuals with cancer. We have a keen interest in developing and applying analyses of circulating tumor DNA (ctDNA) for minimal residual disease detection and therapy monitoring, with the ultimate goal to inform ctDNA-interventional clinical trials.
People
Meet the Team
Our laboratory is home to investigators, post-docs, PhD students, medical students, oncology fellows, staff, and other collaborators from multi-disciplinary fields who are driven to study how the intersection of cancer genomics and immunotherapy can advance precision oncology.
Research
Read about the Latest Discoveries
Our research spans the spectrum of tumor clonal evolution, utilizing cutting edge sequencing technologies coupled with computational analytical frameworks to probe the molecular intricacies that determine therapeutic outcomes and translate them cancer interception strategies.
Lab News
Here’s what’s happening…
Unraveling the evolving genomic landscape of cancer during therapy goes through a long journey of learning… Here’s what’s been happening lately in our lab!
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Stay informed
Blog
Cancer evolution converging on common resistance mechanisms to PARP inhibition: A Molecular Tumor Board discussion.
Precision oncology is revolutionizing the way we treat cancer by tailoring therapies to the genetic makeup of individual tumors. As our understanding of cancer's molecular biology continues to expand, therapies are becoming more targeted, effective, and...
Bridging liquid biopsy discoveries with clinical cancer: Harnessing ctDNA Molecular Response to Predict Clinical Outcomes and Guide Therapeutic Decision Making for Individuals with Lung Cancer.
Posing hypothesis-driven and clinically relevant questions represents one of the pillars of scientific discovery that can be translated in interventions that may improve patient outcomes. And that’s exactly what our research team was able to do with BR.36; a...
C3PO 2024 Postdoctoral Lecture Series
Here are some highlights from yesterday's C3PO Postdoctoral Lecture Series, featuring Dr. Lavanya Sivapalan, Postdoctoral Research Fellow in the Molecular Oncology Lab. In her presentation titled "Longitudinal cell-free tumor load dynamics represent an early endpoint...
Johns Hopkins Kimmel Cancer Center Trainee Research Day 2024
We are excited to share the outstanding posters presented by our team at the Johns Hopkins Kimmel Cancer Center Trainee Research Day, which took place on April 24, 2024. Our researchers showcased innovative projects that are making a significant impact on cancer...
Giving
Support Us
Thank you for taking the time to explore our website. Your interest in our work means a great deal to us. As we strive to advance cancer research and provide innovative solutions, we rely on the support of individuals like you. Whether it’s through donations, volunteering, or spreading awareness about our mission, your contribution can make a meaningful impact on our journey. Please consider supporting our efforts. Together, we can make a difference.
Contact
Get In Touch
Want to collaborate with us? Send us a quick message.