Welcome to the
About
The Molecular Oncology Laboratory
The Molecular Oncology Laboratory is dedicated to advancing cancer research by unraveling the genomic landscape of response and resistance to cancer therapies, with a focus on immunotherapies. Our mission is to comprehensively study the genomic wiring of tumor and immune system interactions and bridge scientific discoveries with clinical cancer care. Through cutting-edge integrative genomic, transcriptomic, single-cell, and liquid biopsy analyses, we aim to capture tumor evolution as the cancer cells undergo therapy-imposed bottlenecks and translate the lessons learned into interventions that improve the clinical outcomes of individuals with cancer. We have a keen interest in developing and applying analyses of circulating tumor DNA (ctDNA) for minimal residual disease detection and therapy monitoring, with the ultimate goal to inform ctDNA-interventional clinical trials.
People
Meet the Team
Our laboratory is home to investigators, post-docs, PhD students, medical students, oncology fellows, staff, and other collaborators from multi-disciplinary fields who are driven to study how the intersection of cancer genomics and immunotherapy can advance precision oncology.
Research
Read about the Latest Discoveries
Our research spans the spectrum of tumor clonal evolution, utilizing cutting edge sequencing technologies coupled with computational analytical frameworks to probe the molecular intricacies that determine therapeutic outcomes and translate them cancer interception strategies.
Lab News
Here’s what’s happening…
Unraveling the evolving genomic landscape of cancer during therapy goes through a long journey of learning… Here’s what’s been happening lately in our lab!
Follow Us
Here's our newest @Hopkins_MTB discussion on convergent evolution of cancer clones to restore homologous recombination via polyclonal PALB2 reversion mutations driving resistance to PARP tx. @HopkinsThoracic @HopkinsMedicine @JennaCanzoniero @MariaFatteh
Here's our newest @Hopkins_MTB discussion on convergent evolution of cancer clones to restore homologous recombination via polyclonal PALB2 reversion mutations driving resistance to PARP tx. @HopkinsThoracic @HopkinsMedicine @JennaCanzoniero @MariaFatteh
Thanks for hosting me for Grand Rounds @YaleMed @yalepathology, wonderful day and stimulating discussions with faculty and young investigators! @HopkinsThoracic @HopkinsMedicine @MolecularOncLab
Thanks for hosting me for Grand Rounds @YaleMed @yalepathology, wonderful day and stimulating discussions with faculty and young investigators! @HopkinsThoracic @HopkinsMedicine @MolecularOncLab
3
Thanks to @ValsamoA of @HopkinsMedicine for presenting #Patholgy Grand Rounds today on “Tracking Tumor Evolution via Integrative Cancer Genomics & Liquid Biopsy Approach” Here’s Dr. Anagnostou w/her host David Rimm, MD, PhD, of @RimmPathology. @YaleCancer @YaleMed @YalePathRes
Stay informed
Blog
Dual Insights in a Blood Draw: Cancer and Immune Cell Footprints in Blood Tests Capture Immunotherapy Outcomes and Toxicity for Patients with Lung Cancer.
Dual Insights in a Blood Draw: Cancer and Immune Cell Footprints in Blood Tests Capture Immunotherapy Outcomes and Toxicity for Patients with Lung Cancer.
Johns Hopkins Kimmel Cancer Center Trainee Research Day 2024
We are excited to share the outstanding posters presented by our team at the Johns Hopkins Kimmel Cancer Center Trainee Research Day, which took place on April 24, 2024. Our researchers showcased innovative projects that are making a significant impact on cancer...
Dual Insights in a Blood Draw: Cancer and Immune Cell Footprints in Blood Tests Capture Immunotherapy Outcomes and Toxicity for Patients with Lung Cancer.
Dual Insights in a Blood Draw: Cancer and Immune Cell Footprints in Blood Tests Capture Immunotherapy Outcomes and Toxicity for Patients with Lung Cancer.
Our team is headed to #AACR24!
We are thrilled to announce that our team is headed to #AACR24!
Giving
Support Us
Thank you for taking the time to explore our website. Your interest in our work means a great deal to us. As we strive to advance cancer research and provide innovative solutions, we rely on the support of individuals like you. Whether it’s through donations, volunteering, or spreading awareness about our mission, your contribution can make a meaningful impact on our journey. Please consider supporting our efforts. Together, we can make a difference.
Contact
Get In Touch
Want to collaborate with us? Send us a quick message.