Welcome to the
About
The Molecular Oncology Laboratory
The Molecular Oncology Laboratory is dedicated to advancing cancer research by unraveling the genomic landscape of response and resistance to cancer therapies, with a focus on immunotherapies. Our mission is to comprehensively study the genomic wiring of tumor and immune system interactions and bridge scientific discoveries with clinical cancer care. Through cutting-edge integrative genomic, transcriptomic, single-cell, and liquid biopsy analyses, we aim to capture tumor evolution as the cancer cells undergo therapy-imposed bottlenecks and translate the lessons learned into interventions that improve the clinical outcomes of individuals with cancer. We have a keen interest in developing and applying analyses of circulating tumor DNA (ctDNA) for minimal residual disease detection and therapy monitoring, with the ultimate goal to inform ctDNA-interventional clinical trials.
People
Meet the Team
Our laboratory is home to investigators, post-docs, PhD students, medical students, oncology fellows, staff, and other collaborators from multi-disciplinary fields who are driven to study how the intersection of cancer genomics and immunotherapy can advance precision oncology.
Research
Read about the Latest Discoveries
Our research spans the spectrum of tumor clonal evolution, utilizing cutting edge sequencing technologies coupled with computational analytical frameworks to probe the molecular intricacies that determine therapeutic outcomes and translate them cancer interception strategies.
Lab News
Here’s what’s happening…
Unraveling the evolving genomic landscape of cancer during therapy goes through a long journey of learning… Here’s what’s been happening lately in our lab!
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Blog
The revolutionary role of immunotherapy in the treatment of cancer
Significant advancements have been made in the therapeutic landscape of cancer, driven by the imperative to develop treatments for patients that are both effective and less toxic. Traditional therapeutic strategies like surgery, chemotherapy, and radiation therapy are...
Hopkins Kimmel newsroom, video, “Capturing Immunotherapy Response in a Blood Drop”
In this study, our group at the Johns Hopkins Kimmel Cancer Center demonstrated that a minimally invasive blood test effectively captures early responses to immunotherapy in patients with advanced lung cancer. By measuring circulating tumor DNA (ctDNA) levels, this...
Webinar on Early ctDNA Molecular Response Enhanced Through Integrated Analyses of Cell-Free DNA and Matched White Blood Cells.
In a webinar hosted by Labroots, Dr. Anagnostou discussed cutting-edge advancements in diagnostics that enable precision oncology, focusing on the integration of circulating cell-free DNA (cfDNA) and matched white blood cell (WBC) analyses. This approach represents a...
2025 Dedication of the Alex Grass Professor of Oncology
In this video, Dr. Valsamo (Elsa) Anagnostou receives the Alex Grass endowed professorship in Oncology. Listen to the program and learn more about Dr. Anagnostou’s journey in cancer research and precision oncology in the video below.
Giving
Support Us
Thank you for taking the time to explore our website. Your interest in our work means a great deal to us. As we strive to advance cancer research and provide innovative solutions, we rely on the support of individuals like you. Whether it’s through donations, volunteering, or spreading awareness about our mission, your contribution can make a meaningful impact on our journey. Please consider supporting our efforts. Together, we can make a difference.
Contact
Get In Touch
Want to collaborate with us? Send us a quick message.